estimate the predictive risk score in patients with chronic hepatitis
This application will help you or medical personnel such as nurses, doctors, nurses or other health workers. to help the function of diagnosing hepatitis suffered by the patient.
This application will estimate a predictive risk score in patients with chronic hepatitis B. with a complex calculation method of gender, age, serum ALT concentration, HBeAg status, and serum HBC DNA levels.
Risk-score table 17 contains points developed and validated with clinical factors. The resulting risk scores are accurate and reliable, with estimated risks correlating well with observed risks.
This risk-prediction instrument can be used by a wide range of health professionals, from general practitioners to experienced hepatologist. It may also provide valuable insights for health authorities needing information for long-term resource planning. and it is hoped that this can provide treatment calculations for patients and those who need good and quality therapy. Hope it is useful
Compared to the HIV virus, the Hepatitis B virus (HBV) is a hundred times more virulent, and ten times more infectious. Most Hepatitis B symptoms are not obvious.
Chronic hepatitis B is a chronic necroinflammatory disease of the liver caused by persistent Hepatitis B virus infection.
Chronic hepatitis B is characterized by positive HBsAg (> 6 months) in the serum, high levels of HBV DNA and ongoing chronic necroinflammatory processes in the liver. Inactive HBsAg carrier is defined as persistent HBV infection of the liver without necroinflammation. Meanwhile, chronic Hepatitis B exacerbation is a clinical condition characterized by an intermittent increase in ALT> 10 times the upper limit of normal value (BANN). The diagnosis of chronic Hepatitis B infection is based on serological examination, virological, biochemical and histological markers.
Serologically, the recommended tests for the diagnosis and evaluation of chronic Hepatitis B infection are: HBsAg, HBeAg, anti-HBe and HBV DNA (4.5). Virological examination, carried out to measure the amount of serum HBV DNA, is very important because it can describe the level of viral replication. The biochemical examination that is important for determining therapeutic decisions is the ALT level. Elevated ALT levels indicate croinflammatory activity.
Therefore, this examination is considered as a prediction of the histology. Patients with ALT levels that show a more severe necroinflammatory process than those with normal ALT. Patients with normal ALT levels have a poor serologic response to antiviral therapy. Therefore, patients with normal ALT levels are considered not to be treated, unless the results of histological examination show an active necroinflammatory process. Meanwhile, the purpose of a histology examination is to assess the level of liver damage, rule out diagnoses of other liver diseases, prognosis and determine anti-viral management.
In general, the symptoms of Hepatitis B are mild. These symptoms can include loss of appetite, discomfort in the stomach, nausea to vomiting, mild fever, sometimes accompanied by joint pain and swelling in the upper right abdomen. After one week the main symptoms will appear, such as the whites of the eyes appearing yellow, the skin of the whole body appearing yellow and the urine the color of tea.
There are 3 possible immune responses given by the body to the Hepatitis B virus after the acute period. The first possibility is that if the body's immune response is adequate, the virus will be cleared and the patient will recover. Second, if the body's immune response is weak then the patient will become an inactive carrier. Third, if the body's response is intermediate (between the two things above) then the disease continues to develop into chronic hepatitis B.
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